Tritospot Cream 15g

Tritospot-Topical-Cream

Topical cream refers to a type of medication that is applied to the skin, usually for localized treatment of skin conditions or to provide pain relief. Topical creams are formulated with a specific active ingredient or a combination of active ingredients, depending on the condition being treated. These creams may be prescription or over-the-counter (OTC) medications.

Topical creams can be used to treat a wide range of skinconditions, including eczema, psoriasis, acne, and rosacea, as well as to relieve pain associated with conditions such as arthritis or muscle strains. They work by delivering medication directly to the affected area, bypassing the digestive system and liver, which can reduce the risk of systemic side effects.

When using topical creams, it is important to follow the instructions provided by the prescribing physician or on the OTC label. In general, topical creams should be applied only to the affected area of the skin and should be used as directed. It is also important to avoid using too much cream, as this can increase the risk of side effects.

chidren  under 12 years perioral dermatitis are contraindicated to the local application of corticosteroid.

As the quantity of hydroquinone absorbed is not evaluated,

Tritospot cream should not be applied on large surfaces or with kidney disease. Topical cream TRITOSPOT For skin hyperpigmentation disorders COMPOSITION: WARNINGS AND PRECAUTIONS: Each 100 gm contains:

Avoid contact with eyes, lips and nasal mucosa. Do not expose the hyper-pigmented treated areas to Intense solar radiation. The corticosteroid may mask the symptoms of a skin allergy reaction to any component of the preparation. Patient should use Tritospot cream for current skin troubles only and not to pass the cream to another person to avoid further browning of the skin and prevent the appearance of skin irritations, patients should protect the treated skin from intense sunlight and UV radiation. In special cases, it is recommended to cover the treated area with adequate sun protection. Hydroquinone 39 Hydrocortisone acetate 19 Tretinoin 20 mg 49 Euselx oily PHARMACEUTICAL FORM:

Topical Cream PHARMACOLOGICAL ACTIONS:

Indications: Different forms of Acquired melanin hyper-pigmentation, such as hyper pigmentation due to scarring, post-traumatic hyper-pigmentation due to drugs, post-inflammatory hyper pigmentation due to phototoxic reactions, freckles.

INTERACTIONS: Pregnancy and Breastfeeding: Reproduction studies in rats and rabbits with doses of topically applied tretinoin showed no effect on fertility or harm to the fetus. There are no controlled studies in humans.

In experimental animals, topical application of corticosteroids teratogenic. There were no controlled studies available neither in animals nor in pregnant women on the effect of Hydroquinone upon topical application.

In those circumstances, the drug should be administered only when absolutely necessary. Even during breastfeeding, use of Tritospot cream should be restricted to cases where it is absolutely necessary. If necessary, avoid treatment in the breast area so that breastfed infant is not in contact with the treated skin area.

POSOLOGY AND MECHANISM OF ACTION:

Adults and adolescents 12 years and older. The cream should be applied sparingly once a day on the hyper pigmented areas. The application must be limited to areas where the skin is changed. Avoid application on large surfaces (application should not exceed 10% of the total surface body).

The treatment duration is on average of seven weeks. Only in exceptional cases, you may consider applying the cream over a longer period, up to three months, taking in consideration the benefits of treatment versus the risks. If no depigmentation appears after three months, stop using the cream.

Application and safety of using Tritospot cream in children under 12 years have not yet been examined.

ABILITY TO DRIVE AND USE MACHINES:

Tritospot cream has no effect on driving or using CONTRAINDICATIONS: machinery. Acquired non-melanin pigmentations, vitiligo and suspicion of melanoma, intolerance to tretinoin or to any other component of the preparation. Acute inflammations and eczema of the skin. Children under 12 years. Skin infections (viral, bacterial including TBC and mycotic origin), reactions to vaccinations, skin ulcers, acne, rosacea and UNDESIRABLE EFFECTS: Frequency: "Very common" (> 1/10), "frequent" (> 1/100, <1/10). "Occasional (>1/1000, <1/100). "Rare" (>1/10,000, <1/1000), "very rare (<1/ 10,000). In rare cases (>1/10,000, <1/1000), skin reactions in the form of erythema, irritation, pruritus,

local application of tretinoin. As a substance that can cause irritation, it should not therefore be applied to wounds, skin lesions or mucous membranes, In humans, the percutaneous absorption of a non-inflamed skin is 2-5% of the applied amount.

Hydroquinone has properties similar to phenols. Hydrocortisone acetate: under normal conditions, only a small portion of the amount of corticosteroid applied topically is systemically available. On the application of Tritospot cream locally, no signs of systemic effects were observed. Penetration and permeation of the active ingredients depend on the place of application, the condition of the skin, the pharmaceutical formulation, age and mode of application.

peeling and bums can manifest especially in early treatment. During treatment of very long duration, adverse local effects such as skin thinning. Vasodilatation, stretch marks and acne-like events may occur in isolated cases (<1/10,000). Increased risk of secondary infections due to local reduction of immune defenses.

During a short use of Tritospot cream (1-3 months), there was no such adverse effects.

A local implementation of hydroquinone may result in very rare cases of Allergic contact dermatitis. Hydroquinone may also cause ochronosis, a gradual blue-black staining of the skin; in this case, stop the treatment. Tritospot cream should be stopped upon the occurrence of bright spots around the treated area or on other parts of the body or when the skin doesn't get clear within 3 months. SPECIAL NOTES: For external use only.

OVER DOSAGE: The drug can be used until the date indicated with "EXP on the package. In overdose. symptoms mentioned under "Undesirable effects may occur more significantly.

STORAGE: PROPERTIES: Tretinoin stimulates epidermal mitosis while causing a thinning and densification of the stratum corneum. Increased proliferation of the epidermal cells causes bleaching of the skin, and thinning of the stratum corneum facilitates the penetration of other active principles applied topically.

Topical application of Hydroquinone causes depigmentation of hyper-pigmented skin by inhibiting the enzymatic oxidation of tyrosine to 3,4-dihydroxyphenylalanine (DOPA) and inhibition of other metabolic processes in melanocytes.

Hydrocortisone acetate anti-inflammatory corticosteroid can cause skin bleaching and may occasionally cause hypo-pigmentation and simultaneously has a clear anti-irritant effect.

Prolonged application may lead to the emergence of local adverse effects such as atrophy possibly in the eyelids. The systemic effect of hydrocortisone acetate can be neglected during application on small areas. Store at a temperature not exceeding 30 °C Keep out of reach of children.

PACK: Carton box containing (AL Tube) of 15 gm or 30 gm with insert leaflet. PHARMACOKINETICS: No absorption studies have been performed with this preparation. A penetrating study was conducted with hydroquinone. Till now, there are no available systemic undesirable effects after EVAPHARMA